The increasing resistance of all kinds of microbes to existing medicines - in particular antibiotics - is one of the gravest global health challenges of our time. If left unchecked, it risks setting public health worldwide to a pre-antibiotic era and undermining a century of progress in health care. Antimicrobial resistance (AMR) has been dubbed "a wicked problem" as it involves a number of sectors with distinct forms of national and international governance and diverse interest - human health care, animal health, food production, agriculture and environmental protection. The main challenges from a human health perspective are conservation of existing antimicrobials, research and development of new ones, and equitable access for all persons in need. Policy, legal and governance questions are at the centre of the current debate, which reached the UN General Assembly in September 2016. Prof. Burci will review the terms of the problem, on-going discussions and initiatives as well as areas of interactions with other global health issues and possible ways forward.